ENHANCED DELIVERY OF VIRAL PARTICLES TO THE STRIATUM AND CORTEX

Provided herein are novel methods for delivering recombinant adeno-associated viral (rAAV) particles to the central nervous system of a mammal (e.g., a human). In aspects, the methods involve administering rAAV particles containing a heterologous nucleic acid to the striatum and causing expression o...

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Bibliographic Details
Main Authors SHIHABUDDIN, Lamya, STANEK, Lisa
Format Patent
LanguageEnglish
Published 27.02.2020
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Summary:Provided herein are novel methods for delivering recombinant adeno-associated viral (rAAV) particles to the central nervous system of a mammal (e.g., a human). In aspects, the methods involve administering rAAV particles containing a heterologous nucleic acid to the striatum and causing expression of the heterologous nucleic acid in at least the cerebral cortex and the striatum of the mammal.
Bibliography:Application Number: SG20191012926V