FORMULATIONS OF AZAINDOLE COMPOUNDS

• Main Authors: SIMONE, Eric, BANDA, Alamelu, SANGHVI, Tapan, STAVROPOULOS, Katherine
• Format: Patent
• Language: English
• Published: 30.07.2018

FORMULATIONS OF AZAINDOLE COMPOUNDS A pharmaceutical composition comprises: a) wt% to 9 5 wt% of a HCl salt of Compound (l) -xH2 0 by the weight of the pharmaceutical composition, wherein x is from 0 to 3; and b) 5 wt% to 9 5 wt% of a filler by the weight of the pharmaceutical composition. Another pharmaceutical composition comprises: a) 1 mg/ mL to 2 0 mg/ mL of Compound (1 ) in water; and b) 0 .0 1 M to0 .1 M of a pharmaceutically acceptable pH modifier. A method of preparing a pharmaceutical composition, comprising providing a mixture of Compound (1 ) that includes the HCl salt of Compound (l)-xH2 0 and the filler. Another method of preparing a pharmaceutical composition comprises mixing the HCl salt of Compound (l)' X3/ 4 0 and the pH modifier to form 1 mg/ mL to 2 0 mg/ mL of Compound (1 ) in water. Methods of reducing the amount of influenza viruses, inhibiting the replication of influenza viruses, andtreating influenza each independently employ such pharmaceutical compositions. No Suitable Figure