MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS

The present invention relates with a process for preparing compounds of Formula I:and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R, R, R, R, and Z are as defined herein, and which are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflamma...

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Main Authors SEO, JEONGBEOB, JIANG, YUTONG, CONDROSKI, KEVIN, RONALD, KOLAKOWSKI, GABRIELLE, R, YANG, HONG-WOON, ANDREWS, STEVEN, WADE, HAAS, JULIA, ZHAO, QIAN
Format Patent
LanguageEnglish
Published 29.10.2015
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Summary:The present invention relates with a process for preparing compounds of Formula I:and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R, R, R, R, and Z are as defined herein, and which are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases;intermediates of formula IIused in the preparation of compounds of formula I and the compound for use in the treatment of the diseases mentioned above of the following formula:
Bibliography:Application Number: SG20151006593X