FOERFARANDE FOER FRAMSTAELLNING AV 7-AMINO-3-SUBSTITUERAD CEFALOSPORINSYRA

Novel cephalosporins which has attached to the exomethylene group at the 3-position of the cephem ring a substituted or unsubstituted aryl, acylamino, aromatic heterocyclic, triazolyl or tetrazolyl group, said aromatic heterocyclic group being attached through a carbon-carbon bond and said triazolyl...

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Bibliographic Details
Main Authors H NARITA, I SAIKAWA, H IMAIZUMI, H TAKI, M TAI, Y WATANABE, Y KONISHI, T INABA, T HIRAKAWA, H SADAKI
Format Patent
LanguageSwedish
Published 25.01.1993
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Novel cephalosporins which has attached to the exomethylene group at the 3-position of the cephem ring a substituted or unsubstituted aryl, acylamino, aromatic heterocyclic, triazolyl or tetrazolyl group, said aromatic heterocyclic group being attached through a carbon-carbon bond and said triazolyl or tetrazolyl group being attached through a carbon-nitrogen bond, and has the following group attached to the amino group at the 7-position: wherein A represents a group of the formula, -CH2- or a group of the formula in which R5 represents a hydrogen atom or an alkyl group, and the bond DIFFERENCE represents syn or anti isomer or their mixture; R3 represents a hydrogen or halogen atom; and R4 represents a hydrogen atom or an amino group which may be protected or substituted. These cephalosporins have a broad antibacterial spectrum, are stable against beta -lactamase produced by bacteria, have a low toxicity, and are well absorbed when administered orally or parenterally.
Bibliography:Application Number: SE19860000195