NYA CEFALOSPORINDERIVAT, FORFARANDE FOR FRAMSTELLNING DERAV SAMT FARMACEUTISK KOMPOSITION DERAV

Novel cephalosporins which has attached to the exomethylene group at the 3-position of the cephem ring a substituted or unsubstituted aryl, acylamino, aromatic heterocyclic, triazolyl or tetrazolyl group, said aromatic heterocyclic group being attached through a carbon-carbon bond and said triazolyl...

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Main Authors 10)I SAIKAWA, 5)T INABA, 4)Y KONISHI, 3)H IMAIZUMI, 1)H SADAKI, 8)M TAI, 6)T HIRAKAWA, 7)H TAKI, 2)H NARITA, 9)Y WATANABE
Format Patent
LanguageSwedish
Published 11.01.1988
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Novel cephalosporins which has attached to the exomethylene group at the 3-position of the cephem ring a substituted or unsubstituted aryl, acylamino, aromatic heterocyclic, triazolyl or tetrazolyl group, said aromatic heterocyclic group being attached through a carbon-carbon bond and said triazolyl or tetrazolyl group being attached through a carbon-nitrogen bond, and has the following group attached to the amino group at the 7-position: wherein A represents a group of the formula, -CH2- or a group of the formula in which R5 represents a hydrogen atom or an alkyl group, and the bond DIFFERENCE represents syn or anti isomer or their mixture; R3 represents a hydrogen or halogen atom; and R4 represents a hydrogen atom or an amino group which may be protected or substituted. These cephalosporins have a broad antibacterial spectrum, are stable against beta -lactamase produced by bacteria, have a low toxicity, and are well absorbed when administered orally or parenterally.
Bibliography:Application Number: SE19810005658