DERIVATIVES OF 10,10-DIALKYLPROSTANIC ACID USED FOR INTRAOCULAR DECOMPRESSION

FIELD: medicine; pharmacology. ^ SUBSTANCE: invention describes application of derivatives of 10,10-dialkylprostanic acid as effective ophthalmic antihypertensive agents. Animal suffering from ocular hypertension or glaucoma is introduced with therapeutically effective amount of composition of gener...

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Bibliographic Details
Main Authors DOND JARIV, NGUEN DZHEREMIA KH
Format Patent
LanguageEnglish
Russian
Published 20.10.2008
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:FIELD: medicine; pharmacology. ^ SUBSTANCE: invention describes application of derivatives of 10,10-dialkylprostanic acid as effective ophthalmic antihypertensive agents. Animal suffering from ocular hypertension or glaucoma is introduced with therapeutically effective amount of composition of general formula : where dotted line indicates presence or absence of bond, cross-hatch wedge designates alpha-configuration and solid triangle designates beta-configuration; B is simple, double or triple covalent bond; n - 0-6; X - CH2, S or O; Y is any pharmaceutically acceptable salt of group CO2H, or group CO2R, CONR2, CONHCH2CH2OH, CON (CH2CH2OH)2, CH2OR, P(O)(OR)2, CONRSO2R, CONR2 or of formula Ia; R - H, C1-6alkyl or C2-6alkenyl; R2 and R3 represent C1-6normal alkyl which can be same or another, and can be connected with each other so that to form ring including carbon atom to which both of them are connected. ^ EFFECT: invention provides higher efficiency of composition and method of treatment. ^ 52 cl, 1 ex, 2 tbl, 8 dwg
Bibliography:Application Number: RU20050129072