HISTONE DEACETYLASE INHIBITOR-CONTAINING PHARMACEUTICAL COMPOSITION

FIELD: organic chemistry, medicine, pharmacology, biochemistry. ^ SUBSTANCE: invention relates a pharmaceutical composition, pharmaceutical combination and a set for treatment of cancer forms mediated by histone deacetylase. Proposed composition and combination comprises the effective amount of benz...

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Bibliographic Details
Main Authors MIGITA KHIDEJUKI, SUGAVARA TATSUO, MATSUBA JASUKHIRO, NAKANISI OSAMU
Format Patent
LanguageEnglish
Russian
Published 27.04.2008
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:FIELD: organic chemistry, medicine, pharmacology, biochemistry. ^ SUBSTANCE: invention relates a pharmaceutical composition, pharmaceutical combination and a set for treatment of cancer forms mediated by histone deacetylase. Proposed composition and combination comprises the effective amount of benzamide derivatives of the formula (5): and other anticancer active substance chosen from group consisting of cisplatin, etoposide, camptothecin, 5-fluorouracil, gemcitabine, paclitaxel, docetaxel, carboplatin, oxaplatin, doxorubicin and vinblastine. Invention provides high effectiveness of treatment and decreasing toxicity. ^ EFFECT: valuable medicinal properties of pharmaceutical composition, enhanced effectiveness of treatment. ^ 106 cl, 13 tbl, 1 dwg
Bibliography:Application Number: RU20050140570