DERIVATIVES OF CARBOXYLIC ACIDS, INHIBITORS OF METASTASIS AND AGENTS ENHANCING CHEMOTHERAPEUTIC ACTIVITY OF ANTITUMOR PREPARATIONS, METHOD FOR ENHANCING EFFECTIVENESS OF CYTOSTATICS, METHOD FOR INHIBITION OF METASTASIZING PROCESS

• Main Authors: KONOVALOVA NINA PETROVNA, LARJUKOVA MARINA VIKTOROVNA, FEDOROV BORIS SERGEEVICH, FADEEV MIKHAIL ARSEN'EVICH, ALDOSHIN SERGEJ MIKHAJLOVICH, SASHENKOVA TAT'JANA EVGEN'EVNA
• Format: Patent
• Language: English; Russian
• Published: 20.03.2007
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

FIELD: organic chemistry, medicine, oncology. ^ SUBSTANCE: invention relates to using dicarboxylic acids of the general formula (2): R-CONH-OH (2) wherein R means -HO-HNCO, -HO-NHCOCH-(OH)CH(OH), -HOOC-CH2CH2, -HO-OCCH=CH as inhibitors of metastasis and agents enhancing chemotherapeutic activity of antitumor preparations. Also, invention relates to a method for enhancing effectiveness of cytostatics in carrying out cytostatic chemotherapy of tumors. Method is carried out by using cytostatics in combination with derivatives of dicarboxylic acids of the formula (2). Also, invention relates to a method for inhibition of metastasizing process. Method is carried out by effect of the known cytostatics and derivatives of dicarboxylic acid of the formula (2) on tumor. Proposed substances provide enhancing antitumor and anti-metastatic activity of known cytostatics based on using derivatives of dicarboxylic acids. ^ EFFECT: valuable medicinal properties of agents and preparations, enhanced effectiveness of metastasizing inhibition. ^ 4 cl, 4 dwg, 7 ex