HETEROCYCLIC COMPOUNDS
FIELD: organic chemistry of heterocyclic compounds, biochemistry. ^ SUBSTANCE: invention relates to new ortho-substituted and N-substituted indoles of the formula (alpha): or (beta): or their pharmaceutically acceptable salts wherein Z1 represents -CR4 or nitrogen atom (N); R4 means hydrogen atom (H...
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Main Authors | , , , , |
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Format | Patent |
Language | English Russian |
Published |
27.02.2006
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Subjects | |
Online Access | Get full text |
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Summary: | FIELD: organic chemistry of heterocyclic compounds, biochemistry. ^ SUBSTANCE: invention relates to new ortho-substituted and N-substituted indoles of the formula (alpha): or (beta): or their pharmaceutically acceptable salts wherein Z1 represents -CR4 or nitrogen atom (N); R4 means hydrogen atom (H), (C1-C6)-alkyl comprising optionally oxygen atom (O) or nitrogen atom (N) possibly substituted with halogen atom, keto-group, 5-6-membered cycloaliphatic radical possibly comprising 1-2 oxygen atoms (O) or nitrogen atom (N); Z2 represents -CH or -CR wherein R means (C1-C6)-alkyl; R1 means compound of the formula: wherein X1 means -CO or its isostere; m = 0, 1; Y represents alkyl that can be substituted; or two Y form in common (C2-C3)-alkylene; n = 0, 1 or 2; Z3 represents -CH; X2 represents -CH, -CH2 or their isostere; Ar represents one or two phenyl groups bound with X2 wherein phenyl can be substituted; R2 represents hydrogen atom (H), (C1-C6)-alkyl or aryl wherein each aryl comprises, possibly, oxygen atom (O) or nitrogen atom (N) and can be substituted. Proposed compounds are selective inhibitors of p38alpha kinase. ^ EFFECT: valuable biochemical properties of compounds. ^ 34 cl, 5 tbl, 23 ex |
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Bibliography: | Application Number: RU19200132199 |