METHOD FOR PREPARING PHARMACEUTICAL PRODUCT

FIELD: organic chemistry, chemical technology, pharmacy. ^ SUBSTANCE: invention relates to a new method for preparing 1-(9H-carbazole-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amine}-2-propanol of the formula (I): ^ and its pharmaceutical salts of acids addition. Method involves interaction of secondar...

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Main Authors BARKOTSI JOZHEF, RATKAI ZOLTAN, GREGOR TAMASH, DOMAN IMRE, NAD' KALMAN, CHELEN'JAK JUDIT, SHIMIG D'JULA, BALAZH LASLO, GREFF ZOLTAN, NEMET NORBERT, SHERESH PETER, DONAT VERETSKEI D'ERD'I, SABO TIBOR, KOTAI NAD' PETER
Format Patent
LanguageEnglish
Russian
Published 10.02.2005
Edition7
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Abstract FIELD: organic chemistry, chemical technology, pharmacy. ^ SUBSTANCE: invention relates to a new method for preparing 1-(9H-carbazole-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amine}-2-propanol of the formula (I): ^ and its pharmaceutical salts of acids addition. Method involves interaction of secondary amine of the formula (V): ^ with epichlorohydrine and synthesized chlorine-containing compound of the formula (VI): ^ reacts with 4-hydroxy-9H-carbazole of the formula: ^ and synthesized benzyl-carvedilol of the formula (VIII): ^ is debenzylated by the catalytic hydrogenation reaction. If necessary, the synthesized compound is subjected for reaction with inorganic or organic acid for preparing its pharmaceutically acceptable salt of acid addition. ^ EFFECT: improved preparing method. ^ 8 ex
AbstractList FIELD: organic chemistry, chemical technology, pharmacy. ^ SUBSTANCE: invention relates to a new method for preparing 1-(9H-carbazole-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amine}-2-propanol of the formula (I): ^ and its pharmaceutical salts of acids addition. Method involves interaction of secondary amine of the formula (V): ^ with epichlorohydrine and synthesized chlorine-containing compound of the formula (VI): ^ reacts with 4-hydroxy-9H-carbazole of the formula: ^ and synthesized benzyl-carvedilol of the formula (VIII): ^ is debenzylated by the catalytic hydrogenation reaction. If necessary, the synthesized compound is subjected for reaction with inorganic or organic acid for preparing its pharmaceutically acceptable salt of acid addition. ^ EFFECT: improved preparing method. ^ 8 ex
Author GREFF ZOLTAN
NAD' KALMAN
DOMAN IMRE
BARKOTSI JOZHEF
CHELEN'JAK JUDIT
KOTAI NAD' PETER
RATKAI ZOLTAN
SABO TIBOR
NEMET NORBERT
DONAT VERETSKEI D'ERD'I
GREGOR TAMASH
SHERESH PETER
SHIMIG D'JULA
BALAZH LASLO
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– fullname: GREGOR TAMASH
– fullname: DOMAN IMRE
– fullname: NAD' KALMAN
– fullname: CHELEN'JAK JUDIT
– fullname: SHIMIG D'JULA
– fullname: BALAZH LASLO
– fullname: GREFF ZOLTAN
– fullname: NEMET NORBERT
– fullname: SHERESH PETER
– fullname: DONAT VERETSKEI D'ERD'I
– fullname: SABO TIBOR
– fullname: KOTAI NAD' PETER
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Title METHOD FOR PREPARING PHARMACEUTICAL PRODUCT
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