METHOD FOR PREPARING PHARMACEUTICAL PRODUCT
FIELD: organic chemistry, chemical technology, pharmacy. ^ SUBSTANCE: invention relates to a new method for preparing 1-(9H-carbazole-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amine}-2-propanol of the formula (I): ^ and its pharmaceutical salts of acids addition. Method involves interaction of secondar...
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Main Authors | , , , , , , , , , , , , , |
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Format | Patent |
Language | English Russian |
Published |
10.02.2005
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Edition | 7 |
Online Access | Get full text |
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Summary: | FIELD: organic chemistry, chemical technology, pharmacy. ^ SUBSTANCE: invention relates to a new method for preparing 1-(9H-carbazole-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amine}-2-propanol of the formula (I): ^ and its pharmaceutical salts of acids addition. Method involves interaction of secondary amine of the formula (V): ^ with epichlorohydrine and synthesized chlorine-containing compound of the formula (VI): ^ reacts with 4-hydroxy-9H-carbazole of the formula: ^ and synthesized benzyl-carvedilol of the formula (VIII): ^ is debenzylated by the catalytic hydrogenation reaction. If necessary, the synthesized compound is subjected for reaction with inorganic or organic acid for preparing its pharmaceutically acceptable salt of acid addition. ^ EFFECT: improved preparing method. ^ 8 ex |
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Bibliography: | Application Number: RU19203107772 |