RECOMBINANT PLASMID DNA PBMC-GAG(A)MOD FOR EXPRESSION OF HUMAN IMMUNODEFICIENCY VIRUS PROTEIN GAG IN EUCARYOTIC CELLS

FIELD: biotechnology, medicine, genetic engineering, immunology. ^ SUBSTANCE: invention proposes plasmid DNA pBMC-gag(A)mod. Plasmid comprises gene encoding the protein gag in human immunodeficiency virus type 1, subtype A. In nucleotides sequence of this gene adenine and/or thymine in codons with p...

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Bibliographic Details
Main Authors KOZLOV A.P, ROMANOVICH A.EH, MURASHEV B.V, MASHARSKIJ A.EH, KLIMOV N.A, DUKHOVLINOV I.V, POLJAKOVA M.S
Format Patent
LanguageEnglish
Russian
Published 10.12.2004
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:FIELD: biotechnology, medicine, genetic engineering, immunology. ^ SUBSTANCE: invention proposes plasmid DNA pBMC-gag(A)mod. Plasmid comprises gene encoding the protein gag in human immunodeficiency virus type 1, subtype A. In nucleotides sequence of this gene adenine and/or thymine in codons with prevalence of adenine and/or thymine are replaced partially for guanine and/or cytosine. Plasmid provides high level of protein gag expression of human immunodeficiency virus in eucaryotic cells. The proposed plasmid can be used for immunization against human immunodeficiency virus type 1 (HIV-1), subtype A. ^ EFFECT: valuable biological and medicinal properties of plasmid. ^ 3 dwg, 1 tbl
Bibliography:Application Number: RU20030116170