SUBSTITUTED 3,7-DIAZABICYCLO[3,3,1]NONANES, FOCUSED LIBRARY AND COMBINATORY LIBRARY

• Main Authors: VVEDENSKIJ V.JU, KHVAT ALEKSANDR VIKTOROVICH, TKACHENKO S.E, SANDULENKO JU.B, IVASHCHENKO A.V, OKUN' IL'JA MATUSOVICH
• Format: Patent
• Language: English; Russian
• Published: 20.05.2004
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

FIELD: organic chemistry, medicine, pharmacology. SUBSTANCE: invention relates to new enantiomeric, diastereomeric or stereoisomeric 3,7- diazabicyclo[3.3.1]nonanes of the general formula (1) as bases or salts of pharmacologically acceptable acids that showed in testing high activity with respect to nicotine receptors. Invention relates also to the focused and combinatory libraries of these compounds. In compounds of the formula (1) R1 represents ; each among R2, R3, R5, R6 represents independently hydrogen atom, inert substituent, NH-protective substituent, electrophilic substituent, nucleophilic substituent; R2 and R3 represent in common: -C(O)-, -C(S)-, -C(O)- C(O)-, -CHR8-, -(CH2)k-CR7R8, S(O)n, n = 1, 2; k = 1-3; R1 and R3 or R1 and R2 represent in common group C=O; R4 represents halogen atom, sulfonyloxy-group (for example, tosyl group) or acyloxy-group (for example, acetate); NR5R6 represent in common azaheterocyclyl or substituted azaheterocyclyl; R7 and R8 each represents independently: hydrogen atom, inert substituent. EFFECT: valuable medicinal and pharmacological properties of compounds. 35 cl, 1 tbl, 15 ex