ARYLPIPERAZINE DERIVATIVES, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT

• Main Authors: SINKHA NEELIMA, DZHEHJN SANDZHAJ, GUPTA DZHANG BAKHADUR, ANAND NITIA, MEKHTA ANITA, SAKSENA ANIL KUMAR
• Format: Patent
• Language: English; Russian
• Published: 20.01.2004
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new arylpiperazine derivatives of the general formula (I): and their pharmaceutically acceptable salts and esters wherein Y represents oxygen atom; Q represents CH; X, Z and Z' each represents independently CH or nitrogen atom; m = 0-1; n = 0-4; R1 and R2 are taken independently among of: hydrogen, fluorine, chlorine, bromine atom, OCH3, OCH2H5, OCH2CF3, CH3, C2H5, CF3, isopropyloxy-group; R3 represents hydrogen atom; R4 and R5 represent hydrogen atom or phenyl with exception that R1 represents Hydrogen atom; R2 represents hydrogen, chlorine atom or CF3; R3,R4,R5 mean hydrogen atom; Y means oxygen atom; Q means CH if m = 0 and n = 1; and with exception that R1 represents hydrogen atom; R2 represents OCH3; R3,R4,R5 mean hydrogen atom; Y means oxygen atom; Q means CH if m = 0 and n = 2. Invention relates also to methods for preparing these compounds, pharmaceutical composition based on thereof eliciting uroselective antagonistic activity with respect to alpha1- -adrenoceptors and to methods for treatment of beneath prostate hypertrophy, vascular diseases, congested cardiac insufficiency and hypertension. Invention provides preparing new compounds eliciting valuable pharmaceutical properties. EFFECT: improved preparing methods, enhanced treatment methods, valuable medicinal properties of compounds. 27 cl, 6 tbl