METHOD FOR PREPARING CHITOSAN SOLUBLE FORMS

• Main Authors: KOMAROV B.A, ALBULOV A.I
• Format: Patent
• Language: English
• Published: 10.11.2003
• Edition: 7
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR CHEMICAL WORKING-UP; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

FIELD: medicine, veterinary science, cosmetics. SUBSTANCE: invention describes method for preparing water-soluble forms of chitosan. Method involves preparing the chitosan homogenous solution, its isolation by treatment with alkaline agent to pH value 6.9-7.5, amorphization of chitosan as it an aqueous suspensions in cavitating or mechanical fields with shifting effect. The interaction of the prepared suspension with inorganic, organic acids or their anhydrides and isolation of the end compound from solutions in demineralized water by method of spraying or sublimating drying. Method involves using chitosan of polyfractional composition by molecular mass (from ~ 100 kDa to a monomer link glucosamine) and deacetylation degree from 68 to >= 95%) in the mole ratio of amino-groups of all chitosan fractions and inorganic acid = 1 : (0.08-1), amino-groups of all chitosan fractions and organic acid = 1 : (0.8-1.2), amino- groups of chitosan fractions and organic acid anhydride = 1 : (1-1.4). Invention provides ecological purity and effectiveness of method for preparing being without usage of organic solvents, expanded spectrum of biological activity owing to the usage of chitosan with polyfractional composition. EFFECT: improved preparing method. 6 ex