METHOD FOR OBTAINING ANTIRABIC VACCINE

veterinary biotechnology. SUBSTANCE: method includes the preparation of inoculation material out of rabic viral strain "Schelkovo- 51", infectioning with inoculation material of interwoven cells culture VNK-21, cultivation of rabic virus, collection of virus-containing liquid, virus inacti...

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Main Authors SKICHKO N.D, KRASUTKIN S.N, ZENOV N.I, IVANOV V.S, MEL'NIK N.V
Format Patent
LanguageEnglish
Russian
Published 27.10.2002
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:veterinary biotechnology. SUBSTANCE: method includes the preparation of inoculation material out of rabic viral strain "Schelkovo- 51", infectioning with inoculation material of interwoven cells culture VNK-21, cultivation of rabic virus, collection of virus-containing liquid, virus inactivation and subsequent preparation of a target product either in a liquid or lyophilized form. Inoculation material is obtained in cellular culture VNK-21. Moreover, the primarily reproduced virus is thermally treated to save 0.001-0.0001% intracerebral murine LD50 in treated population. The obtained virus-bearing suspension containing thermostable viral particles is used to infect cellular culture VNK-21. Thermal treatment of "Schelkovo-51' strain is carried out for 140-160 h at 37-38 C. In case of more productive and technological method the suggested vaccine is of higher immunogenic potency and provides improved protection against rabies. It is explained by the fact that as a result of thermal treatment more resistant valuable various predominate in viral population. EFFECT: higher efficiency in protection against rabies. 1 tbl
Bibliography:Application Number: RU20010134269