METHOD OF PRODUCING TRANSGENIC ANIMAL EXPRESSING HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR IN MAMMARY GLAND AND HYBRID GENE H-GM-1 FOR METHOD REALIZATION

molecular biology, genetic engineering. SUBSTANCE: human granulocyte colony-stimulating factor is prepared by expression of recombinant proteins in mammary gland of transgenic animals. Milk of transgenic animals is used for preparing human granulocyte colony-stimulating factor. Original genic struct...

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Bibliographic Details
Main Authors CHERNYKH V.JA, PROKOF'EV M.I, MEZINA M.N, KOSORUKOV V.S, LAGUTINA I.S, GORODETSKIJ S.I, SHEPEL' N.I
Format Patent
LanguageEnglish
Published 20.10.2000
Edition7
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BEER
BIOCHEMISTRY
CARE OF BIRDS, FISHES, INSECTS
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NEW BREEDS OF ANIMALS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
SPIRITS
TRAPPING
VINEGAR
WINE
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Summary:molecular biology, genetic engineering. SUBSTANCE: human granulocyte colony-stimulating factor is prepared by expression of recombinant proteins in mammary gland of transgenic animals. Milk of transgenic animals is used for preparing human granulocyte colony-stimulating factor. Original genic structures of human granulocyte colony-stimulating factor based on available genomic DNA copy and regulatory genes of milk proteins providing effective secretion of human granulocyte colony-stimulating factor with milk of transgenic animals have been developed. Invention can be used in immunology. EFFECT: improved method of transgenic animal producing. 3 cl, 3 dwg, 2 ex
Bibliography:Application Number: RU19990124719