METHOD OF SYNTHESIS OF CIS-DIAMMINCHLOROPROCAINATE PLATINUM (II) CHLORIDE ELICITING HIGH SOLUBILITY IN WATER AND ANTITUMOR ACTIVITY

chemistry of metalloorganic compounds. SUBSTANCE: invention proposes method of synthesis of the novel compound of platinum (II) with procaine as ligand. Substance of the formula: is synthesized. One of chlorine atom in cis-diamminchloroplatinum is substituted with nitrate-group and the latter is sub...

Full description

Saved in:
Bibliographic Details
Main Authors ZHELIGOVSKAJA N.N, MEL'NIKOV M.JA, SILAEV V.G, TROFIMOV V.A
Format Patent
LanguageEnglish
Published 27.06.2000
Edition7
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSESC01D OR C01F
INORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

Abstract chemistry of metalloorganic compounds. SUBSTANCE: invention proposes method of synthesis of the novel compound of platinum (II) with procaine as ligand. Substance of the formula: is synthesized. One of chlorine atom in cis-diamminchloroplatinum is substituted with nitrate-group and the latter is substituted with procainate ion. Synthesized compound is isolated by cryogenic drying at liquid nitrogen temperature and treated with hydrochloric acid to convert its to chloride form. EFFECT: increased solubility in water as compared with that of cis-platinum, enhanced antitumor activity. 2 tbl, 1 dwg, 1 ex
AbstractList chemistry of metalloorganic compounds. SUBSTANCE: invention proposes method of synthesis of the novel compound of platinum (II) with procaine as ligand. Substance of the formula: is synthesized. One of chlorine atom in cis-diamminchloroplatinum is substituted with nitrate-group and the latter is substituted with procainate ion. Synthesized compound is isolated by cryogenic drying at liquid nitrogen temperature and treated with hydrochloric acid to convert its to chloride form. EFFECT: increased solubility in water as compared with that of cis-platinum, enhanced antitumor activity. 2 tbl, 1 dwg, 1 ex
Author SILAEV V.G
TROFIMOV V.A
ZHELIGOVSKAJA N.N
MEL'NIKOV M.JA
Author_xml – fullname: ZHELIGOVSKAJA N.N
– fullname: MEL'NIKOV M.JA
– fullname: SILAEV V.G
– fullname: TROFIMOV V.A
BookMark eNqNi7sKAjEURLfQwtc_3FILwfWBdcxGM5CHbO4qWy0isZJV0D_wx43iB1gMw-HM9LNOe2tjL3tZxdoX5LcUasdaBYQPSIRpAWEtnNTGl35feingBCvaG8FwlaUxMKGvRqFIGUgksSONnabgTbWBAdcER8d0LEm4IoXBlfWJJOOQ_DDrXk7XRxz9epDRVrHU03i_NfFxP51jG59NWc3zVb5ezmS--GPyBk4YPqk
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
Edition 7
ExternalDocumentID RU2151740C1
GroupedDBID EVB
ID FETCH-epo_espacenet_RU2151740C13
IEDL.DBID EVB
IngestDate Fri Jul 19 12:29:34 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_RU2151740C13
Notes Application Number: RU19980119932
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20000627&DB=EPODOC&CC=RU&NR=2151740C1
ParticipantIDs epo_espacenet_RU2151740C1
PublicationCentury 2000
PublicationDate 20000627
PublicationDateYYYYMMDD 2000-06-27
PublicationDate_xml – month: 06
  year: 2000
  text: 20000627
  day: 27
PublicationDecade 2000
PublicationYear 2000
RelatedCompanies OTKRYTOE AKTSIONERNOE OBSHCHESTVO "MAPO-FOND"
RelatedCompanies_xml – name: OTKRYTOE AKTSIONERNOE OBSHCHESTVO "MAPO-FOND"
Score 2.5175245
Snippet chemistry of metalloorganic compounds. SUBSTANCE: invention proposes method of synthesis of the novel compound of platinum (II) with procaine as ligand....
SourceID epo
SourceType Open Access Repository
SubjectTerms ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSESC01D OR C01F
INORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Title METHOD OF SYNTHESIS OF CIS-DIAMMINCHLOROPROCAINATE PLATINUM (II) CHLORIDE ELICITING HIGH SOLUBILITY IN WATER AND ANTITUMOR ACTIVITY
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20000627&DB=EPODOC&locale=&CC=RU&NR=2151740C1
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT8IwEG8IGvVNUSN-pQ9m0YfFIYPBw2JGt7GabV22DuGJwD4SXgaRGf8A_3GvE9AXfWjS66WXXJPr3bX9XRG6a-VK2lUyRQbXMpdVEcNBlKDK7XYrEU8wWrOq8Lznd51YfRl3xjW02GJhqjqhH1VxRLCoBOy9rPbr1c8hllm9rVw_zhcwtHy2uW5K2-xYQAI1yRzoVsBMRiRC9DCW_FAXnk1TFQKJ0h5E0ZowBms0EKCU1W-PYh-j_QCEFeUJqmVFAx2S7cdrDXTgbe67obsxvfUp-vQs7jATMxtHE587VkQjQRAaySbk4x6k547LQhaEjBjUN7iFA9fg1I89fE_pA67Y1LSw5VJCgTHEDh06OGJuPKAu5RNMffwKE0Ns-CY0TnnsMaAIpyPgnyFsW5w4Mmgz3a3cNIx3erfPUb1YFtkFwommpk9JL8_6vVxNtE4_SUXUlWYC2KTO8iZq_inm8h_eFTr6Bqp35SftGtXLt_fsBlx2Ob-tFvsLm6KQaQ
link.rule.ids 230,309,783,888,25576,76876
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT8IwEG8IGvFNUSN-9sEs-rA4YDB4IAa6jVW3dtk6hCcC-0h4ASIY_wD_ca8T0Bd9aNLrpZdck-vdtf1dEbqrZlrS1FJNBdcyVXUZw0GUoKv1ejWWTzCqk7zwvMeaTqQ_DxvDApptsTB5ndCPvDgiWFQM9r7O9-vlzyGWmb-tXD1OZzC0eLJFx1S22bGEBBqK2etYPjc5UQjpBJHCgo70bIauEUiU9iDCNqQxWIOeBKUsf3sU-wjt-yBsvj5GhXReRiWy_XitjA68zX03dDemtzpBn54lHG5ibuNwxIRjhTSUBKGhakI-7kF67rg84H7ASZeyrrCw73YFZZGH7yl9wDmbmha2XEooMPrYoX0Hh9yNetSlYoQpw68wMcBdZkITVEQeB4oIOgD-KcK2JYijgjbj3cqNg2ind_0MFeeLeXqOcGzoSS1uZWm7lemx0WjHiYy6klQCm_RJVkGVP8Vc_MO7RSVHeO7YpezlEh1-g9abas24QsX123t6De57Pb3JF_4Lj06TXA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=METHOD+OF+SYNTHESIS+OF+CIS-DIAMMINCHLOROPROCAINATE+PLATINUM+%28II%29+CHLORIDE+ELICITING+HIGH+SOLUBILITY+IN+WATER+AND+ANTITUMOR+ACTIVITY&rft.inventor=ZHELIGOVSKAJA+N.N&rft.inventor=MEL%27NIKOV+M.JA&rft.inventor=SILAEV+V.G&rft.inventor=TROFIMOV+V.A&rft.date=2000-06-27&rft.externalDBID=C1&rft.externalDocID=RU2151740C1