METHOD OF SYNTHESIS OF CIS-DIAMMINCHLOROPROCAINATE PLATINUM (II) CHLORIDE ELICITING HIGH SOLUBILITY IN WATER AND ANTITUMOR ACTIVITY

chemistry of metalloorganic compounds. SUBSTANCE: invention proposes method of synthesis of the novel compound of platinum (II) with procaine as ligand. Substance of the formula: is synthesized. One of chlorine atom in cis-diamminchloroplatinum is substituted with nitrate-group and the latter is sub...

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Bibliographic Details
Main Authors ZHELIGOVSKAJA N.N, MEL'NIKOV M.JA, SILAEV V.G, TROFIMOV V.A
Format Patent
LanguageEnglish
Published 27.06.2000
Edition7
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSESC01D OR C01F
INORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:chemistry of metalloorganic compounds. SUBSTANCE: invention proposes method of synthesis of the novel compound of platinum (II) with procaine as ligand. Substance of the formula: is synthesized. One of chlorine atom in cis-diamminchloroplatinum is substituted with nitrate-group and the latter is substituted with procainate ion. Synthesized compound is isolated by cryogenic drying at liquid nitrogen temperature and treated with hydrochloric acid to convert its to chloride form. EFFECT: increased solubility in water as compared with that of cis-platinum, enhanced antitumor activity. 2 tbl, 1 dwg, 1 ex
Bibliography:Application Number: RU19980119932