METHOD OF PREPARING 2-(4-HYDROXYPHENYL)ETHANOL
medicine, preparation of 2-(4-hydroxyphenyl)ethanol (n- tyrosol). SUBSTANCE: in order to prepare 2-4- (hydroxyphenyl)ethanol, 4-bromophenol is made to react with butyl lithium in ether or tetrahydrofuran at 33-34 C for 3-5 hours and then with ethylene oxide at -15- -12 C for 1 hour and at room tempe...
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Main Authors | , , , |
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Format | Patent |
Language | English |
Published |
20.06.2000
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | medicine, preparation of 2-(4-hydroxyphenyl)ethanol (n- tyrosol). SUBSTANCE: in order to prepare 2-4- (hydroxyphenyl)ethanol, 4-bromophenol is made to react with butyl lithium in ether or tetrahydrofuran at 33-34 C for 3-5 hours and then with ethylene oxide at -15- -12 C for 1 hour and at room temperature for 1 hour followed by treatment of reaction mixture with 5-20 wt % of hydrochloric acid solution in water. Yield of desired 2- (4-hydroxyphenyl)ethanol is increased to 80%. EFFECT: more efficient preparation method. 5 cl, 4 ex |
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Bibliography: | Application Number: RU19980114698 |