METHOD OF PREPARING 2-(4-HYDROXYPHENYL)ETHANOL

medicine, preparation of 2-(4-hydroxyphenyl)ethanol (n- tyrosol). SUBSTANCE: in order to prepare 2-4- (hydroxyphenyl)ethanol, 4-bromophenol is made to react with butyl lithium in ether or tetrahydrofuran at 33-34 C for 3-5 hours and then with ethylene oxide at -15- -12 C for 1 hour and at room tempe...

Full description

Saved in:
Bibliographic Details
Main Authors MIKHALEVA A.I, TARASOVA O.A, TROFIMOV B.A, SHMIDT E.JU
Format Patent
LanguageEnglish
Published 20.06.2000
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:medicine, preparation of 2-(4-hydroxyphenyl)ethanol (n- tyrosol). SUBSTANCE: in order to prepare 2-4- (hydroxyphenyl)ethanol, 4-bromophenol is made to react with butyl lithium in ether or tetrahydrofuran at 33-34 C for 3-5 hours and then with ethylene oxide at -15- -12 C for 1 hour and at room temperature for 1 hour followed by treatment of reaction mixture with 5-20 wt % of hydrochloric acid solution in water. Yield of desired 2- (4-hydroxyphenyl)ethanol is increased to 80%. EFFECT: more efficient preparation method. 5 cl, 4 ex
Bibliography:Application Number: RU19980114698