ARYLALIPHATIC AMINOAMIDES OF BENZOIC (SUBSTITUTED BENZOIC), CYCLOHEXANE- AND 1-ADAMANTANE CARBOXYLIC ACIDS SHOWING ANTI-ARRHYTHMIC, TOPICAL ANESTHETIC AND ANALGETIC ACTIVITY

• Main Authors: GOLOVKOV P.V, BEL'TJUKOVA A.G, BORISOVA E.JA, TEREKHOVA O.A, TOLSTIKOV G.A, ELISEEVA I.A, ARZAMASTSEV E.V, CHERKASHIN M.I
• Format: Patent
• Language: English
• Published: 27.05.1999
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention describes new biologically active compounds of the formula (I): C2H5(ROCNH)CH(CH2)n-R1 being when R is C6H5 then R1 is NC4H8O and n = 4, 6, 7; or R1 is NC5H10 and n = 5; or R1 is NC6H12 and n = 6; or R1 is N(C4H9)2 and n = 7; when R is C6H4Br-n then R1 is N(C2H5)2 and n = 4, 6, 7; or R1 is NC5H10 and n = 6, 7; or R1 is NC4H8O and n = 7; or R1 is N(C4H9)2 and n = 7; when R is C6H4Cl-n then R1 is N(CH3)2 and n = 4; or R1 is NC4H8O and n = 4; or R1 is NC5H10 and n = 7; when R is C6H4NO2-n then R1 is N(C2H5)2 and n = 7; when R is C6H4NO2-m, then R1 is N(C2H5)2 and n = 4, 7; or R1 is NC4H8O and n = 6, 7; or R1 is NC5H10 and n = 6; when R is C4H4CH3-n then R1 is NC4H8O and n = 6; or R1 is NC5H10 and n = 6; when R is C6H11 then R1 is NC4H8O and n = 6; or R1 is NC5H10 and n = 6; when R is 1-adamantyl then R1 is NC4H8O and n = 6. Compounds show anti-arrhythmic, topical anesthetic and analgetic activities, they exhibit low toxicity and can be used in medicine. EFFECT: new bioactive compounds, low toxicity. 8 tbl, 27 ex