SYK INHIBITORS

• Main Authors: SWAMINATHAN, SUNDARAMOORTHI, XIONG, JIN-MING, SCHMITT, AARON, C, ZHAO, ZHONGDONG, MITCHELL, SCOTT, A, BLOMGREN, PETER, A, KROPF, JEFFREY, E, LEE, SEUNG, H, CURRIE, KEVIN, S, XU, JIANJUN, LO, JENNIFER, R
• Format: Patent
• Language: English; Serbian
• Published: 31.07.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein R 1 , R 2 , R 3 , and R 4 are as des...