SYK INHIBITORS

The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein R 1 , R 2 , R 3 , and R 4 are as des...

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Main Authors SWAMINATHAN, SUNDARAMOORTHI, XIONG, JIN-MING, SCHMITT, AARON, C, ZHAO, ZHONGDONG, MITCHELL, SCOTT, A, BLOMGREN, PETER, A, KROPF, JEFFREY, E, LEE, SEUNG, H, CURRIE, KEVIN, S, XU, JIANJUN, LO, JENNIFER, R
Format Patent
LanguageEnglish
Serbian
Published 31.07.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein R 1 , R 2 , R 3 , and R 4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts or co-crystals thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.
Bibliography:Application Number: RS2018P000332