2-PYRIDYL SUBSTITUTED IMIDAZOLES AS THERAPEUTIC ALK5 AND/OR ALK4 INHIBITORS

This invention relates to 2-pyridyl substituted imidazoles (I) which are inhibitors of the transforming growth factor-² (TGF-²) type I receptor (ALK5) and/or the activin type I receptor (ALK4), methods for their preparation, and their use in medicine, specifically in the treatment and prevention of...

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Main Authors SHEEN, YHUN, YHONG, PARK, CHUL-YONG, KIM, DAE, KEE, SREENU, DOMALAPALLY, SUBRAHMANYAM, VURA, BALA, RAO, KOTA, SUDHAKAR, JIN, CHENG, HUA, KRISHNAIAH, MADDEBOINA
Format Patent
LanguageEnglish
Serbian
Published 30.03.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to 2-pyridyl substituted imidazoles (I) which are inhibitors of the transforming growth factor-² (TGF-²) type I receptor (ALK5) and/or the activin type I receptor (ALK4), methods for their preparation, and their use in medicine, specifically in the treatment and prevention of a disease state mediated by these receptors.
Bibliography:Application Number: RS2017P001245