AGOMELATINE HYDROBROMIDE HYDRATE AND PREPARATION THEREOF

Agomelatin hidrobromid hidrat prema formuli I:gde, X je Br.Prijava sadrži još 11 patentnih zahteva. The present invention relates to an agomelatine hydrobromide hydrate of formula I wherein X is Br, preparation and use thereof, and to pharmaceutical compositions containing it. The agomelatine hydrob...

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Bibliographic Details
Main Authors YU, Xiong, ZHANG, Peng, ZHU, Xueyan, PAN, Hongjuan, SHAN, Hanbin, YUAN, Zhedong
Format Patent
LanguageEnglish
Serbian
Published 30.06.2016
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Agomelatin hidrobromid hidrat prema formuli I:gde, X je Br.Prijava sadrži još 11 patentnih zahteva. The present invention relates to an agomelatine hydrobromide hydrate of formula I wherein X is Br, preparation and use thereof, and to pharmaceutical compositions containing it. The agomelatine hydrobromide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps.
Bibliography:Application Number: RS2015P000831