CRYSTALLINE FORMS OF HYDROCHLORIDE SALT OF (4A-R,9A-S)-1-(1H-BENZOIMIDAZOLE-5-CARBONYL)-2,3,4,4A,9,9A-HEXAHYDRO-1H-INDENO [2,1-B]PYRIDINE-6-CARBONITRILE AND THEIR USE AS HSD 1 INHIBITORS

Jedinjenje predstavljeno strukturnom formulom:naznačeno time, što je najmanje 50 težinskih procenata jedinjenja u kristalnom obliku.Prijava sadrži još 15 patentnih zahteva. The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in c...

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Main Authors YANG, BING-SHIOU, SICK, SANDRA, ECKHARDT, MATTHIAS, MARTIN, HANS-JUERGEN, SCHUEHLE, MARTIN
Format Patent
LanguageEnglish
Serbian
Published 31.08.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Jedinjenje predstavljeno strukturnom formulom:naznačeno time, što je najmanje 50 težinskih procenata jedinjenja u kristalnom obliku.Prijava sadrži još 15 patentnih zahteva. The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11 -hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
Bibliography:Application Number: RS2015P000205