ADDITION SALTS OF AMINES CONTAINING HYDROXYL AND/OR CARBOXYLIC GROUPS WITH AMINO NICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS

• Main Authors: CARRERA CARRERA, FRANCESC, BOIX BERNARDINI, MARIA CARMEN, PEREZ GARCIA, JUAN BAUTISTA, GARCIA MARTIN, DIGNA JOSÉ
• Format: Patent
• Language: English; Serbian
• Published: 28.02.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Farmaceutski prihvatljiva kristalna adiciona so (i) amina koji sadrži jednu ili više hidroksilnih i/ili karboksilnih grupa s (ii) derivatom aminonikotinske kiseline formule (I),naznačena time,što Ra, Rb, Rc i Rd zasebno predstavljaju grupe odabrane iz atoma vodonika, atoma halogena, C1-4 alkilnih grupa koje se mogu opciono supstituisati s 1, 2, ili 3 supstituenta odabrana iz atoma halogena i hidroksi grupa, i C1-4 alkoksi grupe koje se mogu opciono supstituisati s 1, 2 ili 3 supstituenta odabrana iz atoma halogena i hidroksi grupa, i njihove farmaceutski prihvatljive solvate.Prijava sadrži još 14 patentnih zahteva. The present invention is directed to novel water-soluble pharmaceutically acceptable, crystalline addition salts of (i) an amine containing one or more hydroxyl and/or carboxylic groups with (ii) amino nicotinic acid derivatives of formula (I) wherein R a , R b , R c and R d independently represent groups selected from hydrogen atoms, halogen atoms, C 1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C 1-4 alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and pharmaceutically acceptable solvates thereof.