2-AMINO-7,8-DIHYDRO-6H-PYRIDO[4,3-D]PYRIMIDIN-5-ONES-I, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

• Main Authors: LEVINE, BARRY H, MACHAJEWSKI, TIMOTHY, D, POON, DANIEL, MCBRIDE, CHRISTOPHER, GAO, ZHENHAI, LIN, HIAODONG, COSTALES, ABRAN, BRAMMEIER, NATHAN, RICO, ALICE, DOLAN, JOHN, BARSANTI, PAUL A, DOUGHAN, BRANDON M, GONG, BAOQING, PICK, TERESA, MENDENHALL, KRIS, ANTONIOS-MCCREA, WILLIAM, BRINNER, KRISTIN, TULINSKY, JOHN, ZHOU, YASHEEN, MCKENNA, MAUREEN, SHAFER, CYNTHIA, M, WANG, MICHAEL X, GU, DAN, XIA, YI, RENHOWE, PAUL A
• Format: Patent
• Language: English; Serbian
• Published: 31.12.2011
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Jedinjenje formule (I):ili stereoizomer, tautomer ili farmaceutski prihvatljiv oblik soli, gde je Ra odabran iz grupe koju čine(1) vodonik,(2) halogen,(3) hidroksil,(4) C1-C6 alkoksi,(5) tiol,(6) C1-C6 alkiltiol,(7) supstituisana ili nesupstituisana C1-C6 alkil grupa,(8) amino ili supstituisana amino grupa,(9) supstitusana ili nesupstituisana aril grupa,(10) supstitusana ili nesupstituisana heteroaril grupa, i(11) supstitusana ili nesupstituisana heterociklil grupa;R je odabran iz grupe koju čine(1) vodonik,(2) supstitusana ili nesupstituisana C1-C6 alkil grupa,(3) supstitusana ili nesupstituisana C2-C6 alkenil grupa,(4) supstitusana ili nesupstituisana C2-C6 alkinil grupa,(5) supstitusana ili nesupstituisana C3-C7 cikloalkil grupa,(6) supstitusana ili nesupstituisana C5-C7 cikloalkenil grupa,(7) supstitusana ili nesupstituisana aril grupa,(8) supstitusana ili nesupstituisana heteroaril grupa, i(9) supstitusana ili nesupstituisana heterociklil grupa;Rb je odabran iz grupe koju čine(1) supstitusan ili nesupstituisan C3-C7 cikloalkil,(2) supstitusan ili nesupstituisan C5-C7 cikloalkenil,(3) supstitusan ili nesupstituisan aril,(4) supstitusan ili nesupstituisan heteroaril, i(5) supstitusan ili nesupstituisan heterociklil; is tim da kada je Ra amino grupa, tada Rb nije fenil, 4-alkil-fenil, 4-alkoksi-fenil, ili 4-halo-fenil grupa.Prijava sadrži još 46 patentnih zahteva. Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.