VEGFR-2 AND VEGFR-3 INHIBITORY ANTHRANYLAMIDOPYRYDINES

• Main Authors: HABEREY MARTIN, HUTH ANDREAS, ZORN LUDWIG, THIERAUCH KARL-HEINZ, HESS-STUMP HOLGER, INCE STUART, KRUGER MARTIN, MENRAD ANDREAS
• Format: Patent
• Language: English; Serbian
• Published: 21.09.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

VEGFR-2 and VEGFR-3 inhibitory anthranylamidopyridinamides, the production and use thereof as medicaments for the treatment of diseases caused by persistent angiogenesis and intermediates for production of the compounds are disclosed. Said compounds can be used, for example, in tumour or metastasis growth, psoriasis, Kaposi's sarcoma, restenosis, such as for example, stent-induced restenoses, endometriosis, Crohn's disease, Hodgkin's disease, leukaemia, arthritis, such as rheumatoid arthritis, haemangioma, angiofibroma, eye disease, such as diabetic retinopathy, neovascular glaucoma, renal diseases, such as glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombic microangiopathic syndrome, transplant rejection and glomerulopathy, fibrotic diseases, such as liver cirrhosis, mesangial cell proliferative diseases, artherosclerosis, injuries to nervous tissue and inhibition of the reocclusion of vessels after balloon catheter treatment, in vessel prosthetics, or after the application of mechanical devices to hold open vessels, such as for example, stents, as immune suppressants, as a support for scar-free wound healing, age spots and contact dermatitis. Said compounds may also be used as VEGFR-3 inhibitors in lymphangiogenesis. Opisuju se VEGFR-2 i VEGFR-3 inhibirajući antranilamidopiridinamidi, njihovo dobijanje i primena kao leka za lečenje oboljenja, izazvanih perzistentnom angiogenezom kao i međuproizvodi za dobijanje jedinjenja. Jedinjenja prema pronalasku su primenljiva kao, odnosno kod rasta tumora ili metastaza, psorijaze, Kapozis Sarkoma, restenoza, kao na primer stent-indukovane restenoze, endometrioza, Kronove bolesti, Hočkinove bolesti, leukemije, artritisa, kao reumatoidnog artritisa, hemangioma, angiofibroma, očnih oboljenja, kao dijabetske retinopatije, neovaskulamog glaukoma, bubrežnih oboljenja, kao glomerulonefritisa, dijabetske nefropatije, maligne nefroskleroze, trombičnih mikroangio-patskih sindroma, transplantacionih odbacivanja, i glomerulopatije, fibro-tičnih oboljenja, kao ciroze jetre, oboljenja izazvanih proliferacijom mezangialnih ćelija, arterioskleroze, povreda nervnog tkiva i za suzbijanje reokluzije sudova posle balonske kateterizacije, kod protetike sudova ili posle usađivanja mehaničkih naprava za otvaranje sudova, kao na primer stents kao imunosupresiva, za podršku zarastanja rana bez ožiljaka, kod starosnih fleka i kod kontaktnog dermatitisa.