PROCEDE POUR LA PREPARATION DES 4,4-DIARYLE-2-HYDROXYBUTYLAMINES

A method of preparing diarylhydroxybutylamine compounds of the formula I **(See formula)** or R2 and R3 taken together with the adjacent nitrogen atom to which they are attached, complete a heterocyclic ring selected from methyl or substituted dimethyl pyrrolidine, piperidine, morpholine or pyrrolid...

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Bibliographic Details
Main Author MOLLOY,BARYAN B.,US
Format Patent
LanguageFrench
Romanian
Published 09.09.1982
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A method of preparing diarylhydroxybutylamine compounds of the formula I **(See formula)** or R2 and R3 taken together with the adjacent nitrogen atom to which they are attached, complete a heterocyclic ring selected from methyl or substituted dimethyl pyrrolidine, piperidine, morpholine or pyrrolidine, piperidine and morpholine; and its pharmaceutically acceptable, non-toxic salts, characterized by reacting a 1,2-epoxy 4,4-diarylbutane compound of formula II **(See formula)** where X is as defined above, with at least one equivalent of an amine of the formula **(See formula)** where R2 and R3 are as defined above, at a temperature of between 50º and 180ºC. (Machine-translation by Google Translate, not legally binding)
Bibliography:Application Number: RO19760086310