PROCEDE D'OBTENIR L'ANTIBIOTIQUE A-30912

A process for the preparation of the antibiotic A-30912 mixture which contains the seven factors A, B, C, D, E, F and G is described. This antibiotic mixture is obtained by cultivating an Aspergillus rugulosus which has the deposition number NRRL 8113 under aerobic submerged fermentation conditions...

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Bibliographic Details
Main Authors MICHEL,KARL H.,US, HOEHN,MARVIN M.,US
Format Patent
LanguageFrench
Romanian
Published 15.05.1981
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOUNDS OF UNKNOWN CONSTITUTION
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:A process for the preparation of the antibiotic A-30912 mixture which contains the seven factors A, B, C, D, E, F and G is described. This antibiotic mixture is obtained by cultivating an Aspergillus rugulosus which has the deposition number NRRL 8113 under aerobic submerged fermentation conditions in a nutrient medium which contains substances providing assimilable carbohydrates, nitrogen and inorganic salts. As soon as a significant antibiotic activity has formed, the antibiotic mixture is isolated from the fermentation medium. Each of the 7 factors A to G can be isolated individually from this antibiotic A-30912 mixture. The antibiotic A-30912 mixture and the individual factors contained therein have antifungal activity and they can be employed, in particular, as active substances in compositions for controlling fungal diseases of the skin.
Bibliography:Application Number: RO19760087891