SYSTEM FOR CONTROLLED RELEASE OF MEDICAMENTS BASED ON INORGANIC-ORGANIC HYBRIDS AND PROCESS FOR PREPARING THE SAME
The invention relates to a process for preparing inorganic-organic hybrids based on nano-zeolites and nano-gels, to be used as carriers for the controlled release of medicaments. According to the invention, the process consists in imbibing the natural zeolite, such as clinoptilolite, with a dimethyl...
Saved in:
Main Authors | , , , , , , , |
---|---|
Format | Patent |
Language | English Romanian |
Published |
30.05.2022
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The invention relates to a process for preparing inorganic-organic hybrids based on nano-zeolites and nano-gels, to be used as carriers for the controlled release of medicaments. According to the invention, the process consists in imbibing the natural zeolite, such as clinoptilolite, with a dimethyl sulphur oxide, 5-fluorouracyl or sodium diclofenac solution, up to a medicament : zeolite mass ratio of 1:1...1:3, after which a polyethylene glycol diacrylate aqueous solution containing the reducer tetramethyl diamine is admixed, the aqueous phase being added as drops, while stirring, in cyclohexane which contains two usual emulsifiers, followed by admixing an aqueous solution, as drops, containing the initiator redox system oxidant ammonium persulphate while stirring, and by inverse emulsion polymerization at a temperature of 20...30°C, after which the reaction mass is subjected to centrifugation, the solid part is washed with cyclohexane and lyophilized, to result in zeolitic nano-xerogels with encapsulated medicament having a size of 10...180 nm. |
---|---|
AbstractList | The invention relates to a process for preparing inorganic-organic hybrids based on nano-zeolites and nano-gels, to be used as carriers for the controlled release of medicaments. According to the invention, the process consists in imbibing the natural zeolite, such as clinoptilolite, with a dimethyl sulphur oxide, 5-fluorouracyl or sodium diclofenac solution, up to a medicament : zeolite mass ratio of 1:1...1:3, after which a polyethylene glycol diacrylate aqueous solution containing the reducer tetramethyl diamine is admixed, the aqueous phase being added as drops, while stirring, in cyclohexane which contains two usual emulsifiers, followed by admixing an aqueous solution, as drops, containing the initiator redox system oxidant ammonium persulphate while stirring, and by inverse emulsion polymerization at a temperature of 20...30°C, after which the reaction mass is subjected to centrifugation, the solid part is washed with cyclohexane and lyophilized, to result in zeolitic nano-xerogels with encapsulated medicament having a size of 10...180 nm. |
Author | IORDACHE TANŢA-VERONA SPATARELU PAULA CATALINA SANDU TEODOR ZAHARIA ANAMARIA TEODORESCU SAVA MIRCEA CURSARU BOGDAN RADU ANITA LAURA SÂRBU ANDREI |
Author_xml | – fullname: CURSARU BOGDAN – fullname: ZAHARIA ANAMARIA – fullname: TEODORESCU SAVA MIRCEA – fullname: SPATARELU PAULA CATALINA – fullname: IORDACHE TANŢA-VERONA – fullname: SANDU TEODOR – fullname: RADU ANITA LAURA – fullname: SÂRBU ANDREI |
BookMark | eNqFjLsKg0AQAC2SIq9vyP6AhTFgfd6teqC3snuNlUi4VEEl5v-JBPtUA8Mwx2g3TmM4RG_pxGMDBTFocp6prtEAY41KEKiABo3VqkHnBfLVGSAH1hGXylkdb4Sqy9kaAeUMtEwaRX7TlrFVbF0JvkKQdXSO9s_htYTLxlN0LdDrKg7z1IdlHh5hDJ-eKUlv2T3Lk_R_8QW79Tks |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
DocumentTitleAlternate | SISTEM PENTRU ELIBERARE CONTROLATĂ DE MEDICAMENTE PE BAZĂ DE HIBRIDE ANORGANIC-ORGANICE ŞI PROCEDEU DE OBŢINERE A ACESTUIA |
ExternalDocumentID | RO132747B1 |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_RO132747B13 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 15:08:11 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English Romanian |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_RO132747B13 |
Notes | Application Number: RO20170000105 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220530&DB=EPODOC&CC=RO&NR=132747B1 |
ParticipantIDs | epo_espacenet_RO132747B1 |
PublicationCentury | 2000 |
PublicationDate | 20220530 |
PublicationDateYYYYMMDD | 2022-05-30 |
PublicationDate_xml | – month: 05 year: 2022 text: 20220530 day: 30 |
PublicationDecade | 2020 |
PublicationYear | 2022 |
RelatedCompanies | INSTITUTUL NAŢIONAL DE CERCETARE-DEZVOLTARE PENTRU CHIMIE ŞI PETROCHIMIE - ICECHIM |
RelatedCompanies_xml | – name: INSTITUTUL NAŢIONAL DE CERCETARE-DEZVOLTARE PENTRU CHIMIE ŞI PETROCHIMIE - ICECHIM |
Score | 3.4091897 |
Snippet | The invention relates to a process for preparing inorganic-organic hybrids based on nano-zeolites and nano-gels, to be used as carriers for the controlled... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | HUMAN NECESSITIES HYGIENE MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEDICAL OR VETERINARY SCIENCE NANOTECHNOLOGY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES TRANSPORTING |
Title | SYSTEM FOR CONTROLLED RELEASE OF MEDICAMENTS BASED ON INORGANIC-ORGANIC HYBRIDS AND PROCESS FOR PREPARING THE SAME |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220530&DB=EPODOC&locale=&CC=RO&NR=132747B1 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV3PT8IwFG4IGvWmqPG3PZjdFusGw8titq5zGGiXbho4ETpG9AIEZvz3fa1DvXBa0yYv22tev37re18Rups9Au4pVdpO4QJBUYrYakK6tkdcBWjRnZG2rkYecC95bb8MO8MGet_Uwhid0C8jjggRVUC8V2a9Xv79xIpMbuX6Xn1A1-Ipzv3Iqtmxrhp1iRWFPktFJKhFqS-FxaUPpAs2ziHwpB29idYq--wt1DUpy_-AEh-i3RRszasj1FgtWmifbu5da6G9QX3cDc068tbHaJWNspwNMJA2TAXPpej3WYQl67MgY1jE-EeoUWvzZziEvggLjntcyOeA96hdP3Ey0vk0GQ54hFMpKEyAMQpTkQY6NQLnCcMZGDpBtzHLaWLDy49__TSWYvOV7ilqzhfz8gzh0vGciVM8TPVQUc4m004HQIsUjtudeo46R2fbrFxsH7pEB9rb5hidXKFmtfosrwGdK3VjHPsNzfyLTg |
link.rule.ids | 230,309,786,891,25594,76906 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV3PT4MwFG6WaZw3nZr5cz0YbkSEAV6IgVJkCi0BNNtpWRmLXrZlw_jv-4pMvexE0yYv8JrXrx997ytCt_MHwD0hSlUvDCAoQmiqmGq2ammGALSw59pAViPHzApfB88jc9RC79tamFon9KsWR4SIKiDeq3q9Xv39xPLr3MrNnfiAruVjkDu-0rBjWTVqaIrvOTThPicKIU7KFZY6QLpg4-wBT9qzpTav3Di9ebImZfUfUIIjtJ-ArUV1jFrrZRd1yPbetS46iJvjbmg2kbc5QetsnOU0xkDaMOEsT3kUUR-nNKJuRjEP8I9Qo9Tmz7AHfT7mDA8ZT59cNiRq88ThWObTZNhlPk5STmACaqMwFYkrUyNwHlKcgaFT1A9oTkIVXn7y66dJyrdfaZyh9mK5KHsIl7qlT_XifiaHinI-nZkmgJZW6IY9s3Rxjnq7rFzsHuqjTpjH0SQaspdLdCg9Xx-pa1eoXa0_y2tA6krc1E7-BntFjjs |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=SYSTEM+FOR+CONTROLLED+RELEASE+OF+MEDICAMENTS+BASED+ON+INORGANIC-ORGANIC+HYBRIDS+AND+PROCESS+FOR+PREPARING+THE+SAME&rft.inventor=CURSARU+BOGDAN&rft.inventor=ZAHARIA+ANAMARIA&rft.inventor=TEODORESCU+SAVA+MIRCEA&rft.inventor=SPATARELU+PAULA+CATALINA&rft.inventor=IORDACHE+TAN%C5%A2A-VERONA&rft.inventor=SANDU+TEODOR&rft.inventor=RADU+ANITA+LAURA&rft.inventor=S%C3%82RBU+ANDREI&rft.date=2022-05-30&rft.externalDBID=B1&rft.externalDocID=RO132747B1 |