RECOMBINANT ANTIBODY ACTIVE AGAINST CD44v6

• Main Authors: PATZELT ERIK, ADOLF GUNTHER R
• Format: Patent
• Language: English; Romanian
• Published: 30.10.2003
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention relates to an antibody against an epitope contained in the aminoacid sequence encoded by the variant exon v6 of the CD44 gene, to a hybridoma cell line, to an antibody derivative which may be obtained by chemical or enzymatic modification of said antibody, to a recombinant antibody with the idiotype of this antibody, to a pharmaceutical composition which comprises as an active ingredient the antibody or the antibody derivative, and to the utilization of an antibody or an antibody molecule in procedures for diagnosing in vivo or outside the human or animal body. Invenţia se referă la un anticorp împotriva unui epitop cuprins în secvenţa de aminoacizi codificată de exonul 6 variabil al genei CD44, la o linie celulară hibridom, la un derivat de anticorp care se poate obţine prin modificarea chimică sau enzimatică a acestui anticorp, la un anticorp recombinant cu idiotipul acestui anticorp, la o compoziţie farmaceutică care cuprinde ca ingredient activ anticorpul sau un derivat al acestui anticorp şi la utilizarea unui anticorp sau a unei molecule de anticorp în metode de diagnosticare in vivo sau în afara corpului uman sau animal. ŕ