PROCESS FOR PRODUCING COLLAGENIC FOAM

• Main Authors: VÂLSĂNESCU THEODORA, CHIRIAC LILIANA, IORDĂCHEL RADU, COLT MONICA, IORDĂCHEL CATALIN, BUCEVSCHI MIRCEA DAN, CALOIANU MARIA
• Format: Patent
• Language: English; Romanian
• Published: 28.12.2001
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; WORKING-UP

The invention relates to a process for preparing collagenic foam, used as a biocompatible biomaterial with controllable resorption, revascularization implant, bandage for the treatment of burns or cosmetic product. According to the invention, the process consists in mixing 100 parts of solubilized collagen solution having an intrinsic viscosity [eta] = 5...10 dl/g, at a pH=7 and a temperature of 25° C, having a pH=6...8, a concentration of 0.5...2.5% with 5...15 parts of solution of styrene copolymer and maleic anhydride, with [eta] =0.25...0.75 dl/g in ethyl acetate, having a concentration of 0.1...1.5% at a temperature of 25° C and 1...13 parts of ammonium dodecylbenzene sulphonate solution having a concentration of 1%, successively dosing the compounds, then subjecting the system to mixing at a rotative speed of 500...1,000 rot/min, at a temperature ranging from 5...15° C, for 60...120 min, adding 5...15 parts of ammonium bicarbonate, stirring for 90...180 min in the same conditions, adding 4...8 parts of a solution of chlorine hydride in ethyl alcohol of a concentration of 1N, and mixing continuously for 30...60 min, an then stopping the stirring, leaving the mixture to rest for 30 min, draining the liquid phase, and shaping by moulding the collected foam at a thickness ranging from 1 to 10 mm, drying it in warm-air stream having a temperature ranging from 35 to 40° C and a speed of 5...15 m/s. Invenţia se referă la un procedeu de obţinere a spumei colagenice, utilizată ca biomaterial biocompatibil, cu resorbţie controlată, folosit ca implant pentru revasculizare, pansament pentru vindecarea arsurilor şi preparat cosmetic. Procedeul conform invenţiei constă în aceea că se amestecă 100 părţi de soluţie de colagen solubilizat, cu viscozitatea intrinsecă [eta]=5...10 dl/g, la pH=7 şi 25°C, cu pH=6...8, de concentraţie 0,5...2,5%, cu 5...15 părţi soluţie de copolimer de stiren şi anhidridă maleică, cu [eta]=0,25...0,75 dl/g în acetat de etil la 25°C, în acetat de etil de concentraţie 0,1..1,5% şi 1...13 părţi de soluţie de concentraţie 1% de dodecilbenzensulfonat de amoniu, se dozează succesiv componentele, apoi sistemul se supune amestecării cu o turaţie de 500...1000rot/min, la temperatura de 5...15°C, timp de 60...120 min, se adaugă 5...15 părţi bicarbonat de amoniu, iar după 90...180 min de agitare în aceleaşi condiţii, se adaugă 4...8 părţi de soluţie de acid clorhidric în alcool etilic de concentraţie 1N şi se continuă amestecarea pentru 30 ...60 min, apoi se opreşte agitarea, se lasă amestecul în repaus timp de 30 min, se scurge faza lichidă, iar spuma colectată se profilează prin turnare la grosime de 1...10 mm şi se usucă în curent de aer cald, cu temperatura de 35...45°C şi viteza de 5...15 m/s.