TAXOL DERIVATIVE AND PROCESS FOR PREPARING THE SAME

The present invention relates to a taxol derivative and namely (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate of 4,10 beta-diacetoxy-2 alpha-benzoyloxy-5 beta,20-epoxy-1-hydroxy-9-oxo-19-nor-cyclopropa [g]tax-11-en-13 alpha-yl dihydrate and to a process for preparing the same, said...

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Bibliographic Details
Main Authors DIDIER ERIC, LAVIGNE MICHEL, AUTHELIN JEAN RENE
Format Patent
LanguageEnglish
Romanian
Published 28.07.2000
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a taxol derivative and namely (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate of 4,10 beta-diacetoxy-2 alpha-benzoyloxy-5 beta,20-epoxy-1-hydroxy-9-oxo-19-nor-cyclopropa [g]tax-11-en-13 alpha-yl dihydrate and to a process for preparing the same, said product having remarkable antitumoral and antileukaemic properties. Prezenta inventie se refera la un derivat de taxol si anume dihidrat de (2R,3S)-3-tert-butoxicarbonilamino-2-hidroxi-3-fenilpropionat de 4,10beta-diacetoxi-2alfa-benzoiloxi-5beta,20-epoxi-1-hidroxi-9-oxo-19-nor-ci clopropa[g]tax-11-en-13alfa-il si laun procedeu pentru prepararea acestuia, compus cu proprietati anticanceroase si antileucemice remarcabile.
Bibliography:Application Number: RO19980001069