PROCESS FOR THE ISOLATION OF LOVASTATIN

The present invention relates to a process for the isolation of lovastatin, used as a lipidemic medicine According to the invention, the process comprises extracting the lovastatin from a fermentation medium, mycelium or filtrate of a microorganism capable of producing lovastatin, with butylacetate,...

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Bibliographic Details
Main Authors HAJKO PAVICA, POKORNY MIROSLAV, VESEL TANJA, RADEZ IVAN
Format Patent
LanguageEnglish
Romanian
Published 28.02.2000
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to a process for the isolation of lovastatin, used as a lipidemic medicine According to the invention, the process comprises extracting the lovastatin from a fermentation medium, mycelium or filtrate of a microorganism capable of producing lovastatin, with butylacetate, followed by concentrating the solution under low pressure, at a temperature exceeding 40 degrees C and crystallization
Bibliography:Application Number: RO19950002127