PROCESSO DE PREPARACAO E ACIDOS CARBOXILICOS AZA-HETEROCICLICOS SUBSTITUIDOS EM N E DE COMPOSICOES FARMACEUTICAS

Novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent, the compounds thus having the general formula I (I) wherein Y is wherein R1 and R2 independently are C3-8 cycloalkyl phenyl or thienyl all of which may be optio...

Full description

Saved in:
Bibliographic Details
Main Authors KNUD ERIK ANDERSEN, LARS JACOBS STRAY KNUDSEN, PER OLAF SORENSEN, URSULA SONNEWALD
Format Patent
LanguagePortuguese
Published 30.01.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:Novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent, the compounds thus having the general formula I (I) wherein Y is wherein R1 and R2 independently are C3-8 cycloalkyl phenyl or thienyl all of which may be optionally substituted with halogen, trifluoromethyl, C1-16 alkyl or C1-6 alkoxy; s is 1, 2 or 3; x is -CH2-, -O- or -wherein R3 is hydrogen or C1-6-alkyl; r is 2, 3 or 4; R4 and R5 each represents hydrogen or may together represent a bond and R6 is OH or C1-8-alkoxy; and pharmaceutically acceptable acid addition salts are potent inhibitors of GABA uptake from the synaptic cleft.
Bibliography:Application Number: PT19900095970