DERIVADOS DE AMINA CICLICA

Cyclic amine compounds of formula R1-R2CH-R3 (I) are new. R1 = phenyl optionally substituted by 1-4C alkyl, halo, fluoro-substituted 1-4C alkyl, 1-4C alkoxy, fluoro-substituted 1-4C alkoxy, cyano or nitro; R2 = 1-8C aliphatic acyl optionally substituted by halo, OH, 1-4C alkoxy or cyano; benzoyl opt...

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Bibliographic Details
Main Authors KEMJI YONEDA, KATSUNORI TAKATA, FUMITOSHI ASAI, TERUHIKO INOUE, RYO IWAMURA, JUN-ICHIRO KITA, ATSUHIRO SUGIDACHI, TOSHIHIKO IKEDA, HIROYUKI KOIKE
Format Patent
LanguagePortuguese
Published 31.12.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Cyclic amine compounds of formula R1-R2CH-R3 (I) are new. R1 = phenyl optionally substituted by 1-4C alkyl, halo, fluoro-substituted 1-4C alkyl, 1-4C alkoxy, fluoro-substituted 1-4C alkoxy, cyano or nitro; R2 = 1-8C aliphatic acyl optionally substituted by halo, OH, 1-4C alkoxy or cyano; benzoyl optionally substituted by 1-4C alkyl, halo or 1-4C alkoxy; or (1-4C alkoxy)carbonyl; R3 = optionally condensed 3-7 membered cyclic saturated amino group substituted by optionally protected mercapto or 1-4C alkyl optionally substituted by optionally protected mercapto; CR4R5 (mercapto-protecting groups are 1-20C alkanoyl, 3-20C alkenoyl, benzoyl optionally substituted by 1-4C alkyl, halogen or 1-4C alkoxy); or (1-4C alkoxy)carbonyl; and R4, R5 = H, 1-4C alkyl, carboxy, (1-4C alkoxy) carbonyl, carbamoyl or mono- or di-(1-4C alkyl)carbamoyl.
Bibliography:Application Number: PT19970937814T