PROCESSO PARA A PREPARACAO DE DIOIS DE ESTEROIDES E DE COMPOSICOES FARMACEUTICAS QUE OS CONTEM

The invention relates to DELTA -16 alpha ,17-dihydroxypregnane derivatives of general formula (I), wherein A represents a hydrogen atom, or hydroxyl or trifluoroacetoxy group; X represents a hydrogen or halogen atom with the proviso that if A is a hydrogen atom, X is also a hydrogen atom; R represen...

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Main Authors LASZLO SZPORNY, ARPAD KIRALY, SANDOR HOLLY, ANNA BOOR NEE MEZEI, KRISZTINA SZEKELY, JANOS CSORGEI, CSABA MOLNAR, GYORGY HAJOS, JOZSEF SZUNYOG, JOZSEF TOTH, GYORGY FEKETE, BULCSU HERENYI, LILLA FORGACS
Format Patent
LanguagePortuguese
Published 07.11.1990
Edition5
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:The invention relates to DELTA -16 alpha ,17-dihydroxypregnane derivatives of general formula (I), wherein A represents a hydrogen atom, or hydroxyl or trifluoroacetoxy group; X represents a hydrogen or halogen atom with the proviso that if A is a hydrogen atom, X is also a hydrogen atom; R represents a hydrogen atom, a benzoyl or C1-8 alkanoyl group; and --- represents a single or double bond between the two adjacent carbon atoms, as well as pharmaceutical compositions containing these compounds and a process for their preparation. The compounds of general formula (I) possess valuable antiinflammatory effects and thus may be used as active ingredients in antiinflammatory pharmaceutical compositions. They may also be useful in the preparation of other therapeutically useful steroid derivatives.
Bibliography:Application Number: PT19900093375