PROCESSO PARA A PREPARACAO DE NAFTOTIAZEPINONAS OPTICAMENTE ACTIVAS

A process for preparing the two enantiomers of beta -[(2-amino-1-naphthalenyl)thio]- alpha -hydroxy-4-methoxybenzenepropionic acid comprising resolution of rac- beta -[(2-amino-1-naphthalenyl)thio]- alpha -hydroxy-4-methoxybenzenepropanoic acid by means of (+)-1-(p-hydroxybenzyl)-1,2,3,4,5,6,7,8-oct...

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Bibliographic Details
Main Author ERNO MOHACSI
Format Patent
LanguagePortuguese
Published 30.11.1989
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process for preparing the two enantiomers of beta -[(2-amino-1-naphthalenyl)thio]- alpha -hydroxy-4-methoxybenzenepropionic acid comprising resolution of rac- beta -[(2-amino-1-naphthalenyl)thio]- alpha -hydroxy-4-methoxybenzenepropanoic acid by means of (+)-1-(p-hydroxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline and, if desired, conversion of the enantiomers obtained into the optically active naphtho[1,2-b][1,4]thiazepin-4(5H)-ones of the general formulae wherein R is hydrogen, lower alkanoyl, lower cycloalkylcarbonyl or one of the groups -CO-O-(C1-C5 alkyl) and -CO-(CH2)m-O(C1-C3 alkyl) and m is 1 or 2, which are known calcium channel blockers and accordingly are useful as agents for lowering blood pressure and treating ischemia.
Bibliography:Application Number: PT19890090503