PROCESSO PARA A PREPARACAO DE COMPOSTOS AFINS DAS AVERMECTINAS UTEIS COMO AGENTES ANTIPARASITICOS

• Main Authors: MICHAEL JOHN WITTY, BERNARD JOSEPH BANKS
• Format: Patent
• Language: Portuguese
• Published: 29.07.1994
• Edition: 5
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; DERIVATIVES THEREOF; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS; TRAPPING

Antiparasitics comprising Avermectin derivatives of formula (I): wherein the broken line between the 22-23 position represents an optional double bond and wherein either R is H or OH and the double bond is absent, or the double bond is present and R is absent; R is a C1-C6 alkyl group substituted by one oxo or one or more hydroxy groups or by a single oxygen atom on two adjacent carbon atoms to form an oxirane ring, or R is a C1-C5 alkyl group substituted by a (C1-C6 alkoxy) carbonyl group, said substituents on R being attached to either or both a terminal carbon atom and a carbon atom adjacent to a terminal. carbon atom of R ; and R is H or CH3; or, when R is substituted by oxo, a (C1-C4 alkyl) acetal or ketal derivative thereof.