TRIAZOLONAS UTILIZADAS COMO INIBIDORES DE SINTESE DA APOLIPROTEINA B

The present invention concerns novel compounds of formula (I).wherein R1 is C1-10alkyl, C3-7cycloalkyl or C1-6alkyl substituted with C3-7cycloalkyl; R2 is hydrogen or C1-6alkyl; Alk represents C1-3alkanediyl; -A- represents a bivalent radical of formula -CH=CH-N=CH- (a), -N=CH-N=CH- (b), -CH=N-N=CH-...

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Bibliographic Details
Main Authors PAUL AUGUST CLEMENT LUYTS, JAN HEERES, DIDIER ROBERT GUY G. DE CHAFFOY DE COURCELLES, LEO JACOBUS JOZEF BACKX
Format Patent
LanguagePortuguese
Published 29.04.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention concerns novel compounds of formula (I).wherein R1 is C1-10alkyl, C3-7cycloalkyl or C1-6alkyl substituted with C3-7cycloalkyl; R2 is hydrogen or C1-6alkyl; Alk represents C1-3alkanediyl; -A- represents a bivalent radical of formula -CH=CH-N=CH- (a), -N=CH-N=CH- (b), -CH=N-N=CH- (c), -CH=CH-CH=N- (d); in said bivalent radicals a hydrogen atom may be replaced by C1-6alkyl; and Ar is unsubstituted phenyl; phenyl substituted with up to two substituents selected from halo, C1-6alkyl or C1-6alkyloxy; unsubstituted naphthyl; or naphthyl substituted with up to two substituents selected from halo, C1-6alkyl or C1-6alkyloxy; the stereochemically isomeric forms thereof, and the pharmaceutically acceptable acid addition salts thereof. The present invention further comprises the pharmaceutical compositions comprising compounds of formula (I), the preparation thereof as well as the use as a medicine in the treatment of hyperlipidemia.
Bibliography:Application Number: PT19960910968T