PROCESSO PARA A PREPARACAO DE AZETIDINONA-1-OXOACETATO POR OXIDACAO DO 2-HIDROXIACETATO CORRESPONDENTE

A process for production of a 2-azetidinone-1-oxoacetate of the formula useful as an intermediate for preparation of 2-SR -substituted-2-penem-3-carboxylate antibacterial agents; R is a conventional hydroxy protecting group, R is certain carboxy protecting groups and R is (C1-C6)alkyl, and m and n a...

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Bibliographic Details
Main Authors BERKELEY WENDELL CUE, JR, DONALD KLEIN PIRIE
Format Patent
LanguagePortuguese
Published 30.06.1992
Edition5
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:A process for production of a 2-azetidinone-1-oxoacetate of the formula useful as an intermediate for preparation of 2-SR -substituted-2-penem-3-carboxylate antibacterial agents; R is a conventional hydroxy protecting group, R is certain carboxy protecting groups and R is (C1-C6)alkyl, and m and n are each 0, 1 or 2; which comprises contacting a corresponding (2-oxo-1-azetidinyl)-N-2-hydroxyacetate ester of the formula with manganese dioxide in a reaction-inert organic solvent at 0-50 DEG C.
Bibliography:Application Number: PT19880087000