PROCESSO PARA A PREPARACAO DE N-SULFAMIL-3-(2-GUANIDINO-TIAZOL-4-IL-METILTIO)-PROPIONAMIDINA

The invention relates to a new process for the preparation of N-sulfamyl-3-(2-guanidinothiazol-4-yl-methylthio)-propionitrile (famotidine) of the formula (I) (I) by S-alkylation of 2-guanidino-thiazol-4-yl-methanethiol obtained from S-(2-guanidino-thiazol-4-yl-methyl)-isothiourea dihydrochloride of...

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Bibliographic Details
Main Authors KALMAN HARSANYI, ISTVAN SZABADKAI, GYOERGY DOMANY, BELA HEGEDUES, PETER BOD, EVA FEKECS, ERIK BOGSCH, FERENC TRISCHLER, EVA CSONGOR
Format Patent
LanguagePortuguese
Published 01.10.1986
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a new process for the preparation of N-sulfamyl-3-(2-guanidinothiazol-4-yl-methylthio)-propionitrile (famotidine) of the formula (I) (I) by S-alkylation of 2-guanidino-thiazol-4-yl-methanethiol obtained from S-(2-guanidino-thiazol-4-yl-methyl)-isothiourea dihydrochloride of the formula (III) (III) by in situ treatment with a base, which comprises carrying out S-alkylation with a N-sulfamyl-3-halopropionamidine of the formula (II) (II) wherein X stands for halogen.
Bibliography:Application Number: PT19860083348