PROCEDE DE PREPARATION DE L-DI OU TRIPEPTIDES POSSEDANT UNE ACTIVITE BIOLOGIQUE UTILISABLE EN MEDECINE HUMAINE ET VETERINAIRE ET DE MEDICAMENTS LES CONTENANT

• Main Authors: BERNARD DANREE, JEAN-YVES, CLAUDE ROUSSEAU, MONIQUE LE BRETON, JEAN-LUC MORINIERE, ODILE CHASSERAY
• Format: Patent
• Language: French
• Published: 01.07.1986
• Edition: 4
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS BASED THEREON; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR PREPARATION OR CHEMICAL WORKING-UP; VINEGAR; WINE

A process for the synthesis of phosphonic di- or tripeptides of L configuration by reaction of an alpha -aminoacid or of a carboxylic dipeptide with an alpha -aminophosphonic acid or of an alpha -aminocarboxylic acid with a phosphonic dipeptide of L configuration, the reaction being carried out in the presence of an enzyme such as papain with phase separation; the invention also relates to the new products obtained and to medicines containing the said phosphonic di- or tripeptides.