PROCESS FOR PREPARING POLYETHER ANTIBIOTICS AND OF AGENTS CONTAINING THE SAME

Cpds. of formula (I) and their salts are new. In (I) R is 2-7C alkyl or lower hydroxyalkyl. Pref. R is ethyl; 2-hydroxyethyl; n-hexyl; 4-hydroxybutyl; 2- or 3-hydroxypropyl, or S or R 3-hydroxybutyl. (I) are made from antibiotics X-14868A (i.e. the cpd. where R is H) by reaction with ROH in presence...

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Bibliographic Details
Main Authors JOHN WESTLEY, LILIAN H. SELLO, LOUISE H. FOLEY
Format Patent
LanguageEnglish
Published 30.05.1986
Edition4
Subjects
CHEMISTRY
DERIVATIVES THEREOF
FODDER
FOODS OR FOODSTUFFS
HUMAN NECESSITIES
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Summary:Cpds. of formula (I) and their salts are new. In (I) R is 2-7C alkyl or lower hydroxyalkyl. Pref. R is ethyl; 2-hydroxyethyl; n-hexyl; 4-hydroxybutyl; 2- or 3-hydroxypropyl, or S or R 3-hydroxybutyl. (I) are made from antibiotics X-14868A (i.e. the cpd. where R is H) by reaction with ROH in presence of ion-exchange resin, in acid form. The alcohol or diol may be used as solvent and is typically at room temp. The same method can also be used to prepare the known methyl ether. (I) are useful as antibiotics, anticoccidiosis and antimalarial agents, antiinflammatories and also for improving food utilisation in ruminants and pigs. The pref. daily dose is 0.03-0.075 mg/kg. -
Bibliography:Application Number: PT19830077750