AMINOPIRANOS SUBSTITUIDOS POR ACILO COM UM EFEITO MODULADOR SOBRE OS CANAIS DE CALCIO

Treatment of CNS conditions using acyl-substd. amino-pyrans of formula (I) and their salts is new. A = 6-10C aryl or pyridyl, opt. up to three times substd. by NO2, CN, Ph, halo, CF3, 1-6C alkylthio or 1-6C alkoxy; R1 = 1-8C alkyl; R2 = 1-6C alkyl; R3,R4 = H, 1-6C alkyl or 1-6C acyl; R5 = 1-8C alkyl...

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Bibliographic Details
Main Authors JEAN-MARIE-VIKTOR DE VRY, FRANK MAULER, HANS-GEORG HEINE, KLAUS URBAHNS, BODO JUNGE, REILINDE WITTKA
Format Patent
LanguagePortuguese
Published 30.04.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Treatment of CNS conditions using acyl-substd. amino-pyrans of formula (I) and their salts is new. A = 6-10C aryl or pyridyl, opt. up to three times substd. by NO2, CN, Ph, halo, CF3, 1-6C alkylthio or 1-6C alkoxy; R1 = 1-8C alkyl; R2 = 1-6C alkyl; R3,R4 = H, 1-6C alkyl or 1-6C acyl; R5 = 1-8C alkyl or 1-8C alkoxy. Four cpds. falling within the above definitions are new i.e.: 5-acetyl-2-amino-6-methyl-4-(2,3-dichlorophenyl)-4H-pyran-3- carboxylic acid methyl ester (Ia), 5-acetyl-2-amino-6-methyl-4-(3,4-dichlorophenyl)-4H-pyran-3- carboxylic acid methyl ester, 5-acetyl-2-acetylamino-6-methyl-4-(2,3-dichlorophenyl)-4H-pyran- 3-carboxylic acid methyl ester, 5-acetyl-2-amino-6-methyl-4-(3-nitrophenyl)-4H-pyran-3-carboxylic acid methyl ester.
Bibliography:Application Number: PT19960112426T