PROCESSO PARA A PREPARACAO DE UM CLODRONATO

PCT No. PCT/FI94/00509 Sec. 371 Date Aug. 6, 1996 Sec. 102(e) Date Aug. 6, 1996 PCT Filed Nov. 11, 1994 PCT Pub. No. WO95/13054 PCT Pub. Date May 18, 1995The object of the invention is a process for preparing a clodronate preparation. The process is characterized in that clodronate is crystallized a...

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Bibliographic Details
Main Authors ESKO POHJALA, HEIKKI NUPPONEN, KARI LEHMUSSAARI
Format Patent
LanguagePortuguese
Published 30.11.2001
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PCT No. PCT/FI94/00509 Sec. 371 Date Aug. 6, 1996 Sec. 102(e) Date Aug. 6, 1996 PCT Filed Nov. 11, 1994 PCT Pub. No. WO95/13054 PCT Pub. Date May 18, 1995The object of the invention is a process for preparing a clodronate preparation. The process is characterized in that clodronate is crystallized as disodium clodronate tetrahydrate from an aqueous solution of disodium clodronate; the resulting disodium clodronate tetrahydrate is dry granulated by compressing in such a way that the crystal structure of the disodium clodronate tetrahydrate is preserved and by crumbling and screening the mass to granules of a sutiable size, the dry granulated disodium clodronate tetrahydrate is optionally mixed with suitable excipients, such as filling agents and gliding agents and, if necessary, disintegrants.
Bibliography:Application Number: PT19950900155T