CELULAS ENDOTELIAIS TRANSFORMADAS

Endothelial cells which express a protein having I kappa B activity such that NF kappa B activation of the cells is substantially blocked may be prepared by altering the genetic material of the cells so that I kappa B activity is expressed continuously, immediately following endothelial cell activit...

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Bibliographic Details
Main Authors FRITZ H. BACH, RAINER DE MARTIN
Format Patent
LanguagePortuguese
Published 31.08.2000
Edition6
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BEER
BIOCHEMISTRY
CARE OF BIRDS, FISHES, INSECTS
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NEW BREEDS OF ANIMALS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
SUGARS
TRAPPING
VINEGAR
WINE
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Summary:Endothelial cells which express a protein having I kappa B activity such that NF kappa B activation of the cells is substantially blocked may be prepared by altering the genetic material of the cells so that I kappa B activity is expressed continuously, immediately following endothelial cell activiting stimuli or on demand in response to a predetermined external stimulus e.g. by introducing heterologous I kappa B coding sequences or promoters into the cells. Organs and tissue comprising such endothelial cells are useful in transplantation e.g. xenotransplantation, as they are advantageously less susceptible to rejection.
Bibliography:Application Number: PT19930924544T